α-Glucosidase inhibitors from the bark of Mangifera mekongensis

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α-Glucosidase inhibitors from the bark of Mangifera mekongensis

BACKGROUND Mangifera mekongensis (Anacardiaceae) is cultivated for its edible fruit and has been used in traditional Vietnamese medicine for its anti-aging properties and for treating diabetes, vermifuge, and dysentery. As part of a search for biologically active compounds with reduction of the rate of glucose absorption, a screening has been initiated to evaluate natural product extracts for t...

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The α-glucosidase inhibitory activity of an aqueous extract and compounds from the aerial parts of V. corymbosa was demonstrated with yeast and rat small intestinal α-glucosidases. The aqueous extract inhibited yeast α-glucosidase with a half maximal inhibitory concentration (IC50) of 28.6 μg/mL. Bioassay-guided fractionation of the extract led to the isolation of several compounds, including o...

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Loddigesiinols G-J: α-glucosidase inhibitors from Dendrobium loddigesii.

Four new polyphenols, loddigesiinols G-J (compounds 1-4) and a known compound, crepidatuol B (5), were isolated from the stems of Dendrobium loddigesii that have long been used in Traditional Chinese Medicine and have recently been used to treat type 2 diabetes. Compounds 1-5 structures were elucidated based on spectroscopic analysis. The absolute configurations of compounds 1-4 were determined...

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Nine new compounds from the root bark of Lycium chinense and their α-glucosidase inhibitory activity

State Key Laboratory of Bioactive Substance a of Materia Medica, Chinese Academy of Medic Beijing 100050, People's Republic of China. E State Key Laboratory Breeding Base of Da Chinese Materia Medica, China Academy 100700, People's Republic of China † Electronic supplementary information (E IR, and ECD spectra. See DOI: 10.1039/c6 ‡ These authors contributed equally. Cite this: RSC Adv., 2017, ...

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Molecular docking studies of some flavone analogues as α-Glucosidase inhibitors

Background: High Blood glucose levels is one of the main problems in diabetes. α-glucosidase with decomposition of polysaccharides increases the absorption of carbohydrates from the intestine, resulting in blood glucose upsurge. Inhibition of this enzyme is one of the most important strategies for treatment of diabetes. Objective: The aim of this study was to investigate in silico inhibitory ef...

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ژورنال

عنوان ژورنال: Chemistry Central Journal

سال: 2016

ISSN: 1752-153X

DOI: 10.1186/s13065-016-0193-9